Humoral immune responses in patients with acute Schistosoma mansoni infection who were followed up for two years after treatment.
Clin Infect Dis
; 24(3): 304-8, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9114177
ABSTRACT
Eighteen patients with acute Schistosoma mansoni infection were followed up for 2 years after treatment with praziquantel or oxamniquine. Cure rates, clinical features, abdominal ultrasonographic findings, and specific humoral responses were determined at 2-, 6-, and 24-month follow-ups. Fourteen patients (77.8%) were considered parasitologically cured. Levels of IgA antibody to soluble egg antigen (SEA) and IgM antibody to keyhole limpet hemocyanin (KLH) became negative or decreased to the cutoff level for chronic infection 2 months after treatment, while levels of IgG antibody to KLH declined between 12 and 24 months after treatment. Levels of IgM and IgG antibodies to saline worm adult protein as well as IgM and IgG antibodies to SEA remained positive during the follow-up period. Discrete lymph node enlargement and hepatomegaly were still present in six of the eight cured children 2 years after treatment, while complete regression was observed in adults. In our group of patients, in addition to presenting with more intense clinical manifestations, children were cured less often and had slower abatement of symptomatology after treatment than adults.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Schistosoma mansoni
/
Esquistosomiasis mansoni
/
Anticuerpos Antihelmínticos
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Adult
/
Animals
/
Child
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Clin Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil