Carotid atherosclerosis and serum lipoprotein(a) concentrations in patients with NIDDM.
Diabetes Care
; 20(5): 829-31, 1997 May.
Article
en En
| MEDLINE
| ID: mdl-9135950
ABSTRACT
OBJECTIVE:
To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN ANDMETHODS:
We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT values and number of plaques.RESULTS:
Serum Lp(a), but not lipid and apoprotein levels, increased significantly with increasing IMT (20.0 +/- 2.3, 24.7 +/- 3.3, and 39.8 +/- 4.3 mg/dl [mean +/- SE], respectively, P < 0.001). Serum Lp(a) increased with increasing number of plaques (18.4 +/- 2.5 mg/dl in 59 subjects with no plaques, 25.8 +/- 2.5 mg/dl in 24 subjects with 1 plaque, and 38.7 +/- 5.1 mg/dl in 34 subjects with more than 1 plaque; P < 0.05). Furthermore, the mean IMT and Lp(a) levels in the subjects with cerebrovascular disease (CD) were significantly higher than in those without CD (1.25 +/- 0.04 mm and 41.2 +/- 4.7 mg/dl vs. 1.08 +/- 0.03 mm and 22.2 +/- 1.9 mg/dl; P < 0.005). The mean IMT and Lp(a) levels were higher in subjects with ischemic heart disease (IHD) than in those without IHD, although statistical significance was not observed (1.21 +/- 0.06 mm and 31.7 +/- 4.7 mg/dl vs. 1.10 +/- 0.03 mm and 27.0 +/- 2.4 mg/dl, respectively).CONCLUSIONS:
Elevated serum Lp(a) concentrations are associated with carotid atherosclerosis in NIDDM subjects.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arteriosclerosis
/
Enfermedades de las Arterias Carótidas
/
Lipoproteína(a)
/
Diabetes Mellitus Tipo 2
/
Angiopatías Diabéticas
Tipo de estudio:
Diagnostic_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Diabetes Care
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón