[Immunohistochemical study of thymidine phosphorylase in uterine cervical intraepithelial neoplasia].
Rinsho Byori
; 45(5): 483-6, 1997 May.
Article
en Ja
| MEDLINE
| ID: mdl-9170977
ABSTRACT
Studies have shown that thymidine phosphorylase (TdRPase) activity in various tumors is higher than that in normal tissues. We studied the immunohistochemical localization of TdRPase in uterine cervical intraepithelial neoplasia (CIN) using monoclonal antibody against TdRPase. Sixty-nine patients were studied CIN 1, 14; CIN 2, 15; CIN 3 (severe dysplasia), 23; CIN 3 (carcinoma in situ), 17. Immunoreactivity for TdRPase was found in 29% of CIN 1, 40% of CIN 2, 70% of CIN 3 (severe dysplasia), and 88% of CIN 3 (carcinoma in situ), showing increasing incidence with the progression of tumor grade. Furthermore, in higher grade tumor, more immunoreactive cells were found with increased intensity of immunoreaction. Both nucleus and cytoplasm of atypical cells showed immunoreactivity in most TdRPase positive cases, while either nucleus or cytoplasm was positive in a few cases. The stromal tissues were negative for the antibody except 3 cases of CIN 3 (carcinoma in situ) in which the stromal tissues adjacent to the tumor was positive. Our data suggest that immunoreactivity of TdRPase in CIN may correlate with the grade of CIN.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Timidina Fosforilasa
/
Biomarcadores de Tumor
/
Neoplasias del Cuello Uterino
Límite:
Female
/
Humans
Idioma:
Ja
Revista:
Rinsho Byori
Año:
1997
Tipo del documento:
Article
Pais de publicación:
JAPAN
/
JAPON
/
JAPÃO
/
JP