Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.
Exp Neurol
; 145(1): 89-92, 1997 May.
Article
en En
| MEDLINE
| ID: mdl-9184112
ABSTRACT
Elderly subjects (65-76 years) were tested for recall of nonsense syllables prior to and after oral administration of 1-(quinoxalin-6 ylcarbonyl)piperidine (CX516), a centrally active drug that enhances currents mediated by AMPA-type glutamate receptors. A significant and positive drug effect was found for delayed (5 min) recall at 75 min posttreatment; average scores for the highest dose group were more than twofold greater than for the placebo group. The drug had no evident influence on heart rate or self-assessment of several psychological variables.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Recuerdo Mental
/
Envejecimiento
/
Receptores AMPA
/
Dioxoles
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Exp Neurol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos