Diuretics in hypertension.
Kidney Int Suppl
; 59: S36-8, 1997 Jun.
Article
en En
| MEDLINE
| ID: mdl-9185102
Despite the consistent reduction in the incidence of stroke and coronary events demonstrated in numerous clinical trials in young and elderly hypertensive subjects, the use of diuretics has declined as a first-line therapy in hypertension. The metabolic dose-dependent side effects and the increasing availability of new drugs appear the two main reasons for the decline. Although the neutral metabolic effects and the perception of a more physiological approach to hypertension has been advocated with the newer agents, no definite proof has been reported on the long-term effects on cardiovascular end-points. Many of adverse effects of diuretics can be limited by the use of low doses. For this reason, as well as their efficacy, safety, and cost-effectiveness, diuretics should remain a first-line therapy for hypertensive patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diuréticos
/
Hipertensión
Límite:
Humans
Idioma:
En
Revista:
Kidney Int Suppl
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Estados Unidos