A chromosome 18 genetic linkage study in three large Belgian pedigrees with bipolar disorder.
J Affect Disord
; 43(3): 195-205, 1997 May.
Article
en En
| MEDLINE
| ID: mdl-9186790
ABSTRACT
The contribution of genetic factors to the susceptibility for affective disorders has been firmly established. Recent reports found evidence for a susceptibility locus for affective disorders in 2 regions on chromosome 18. We describe 3 large Belgian pedigrees with multiple patients with affective disorders. Both chromosome 18 regions were investigated in the 3 families, using parametric and nonparametric segregation methods. In the pericentromeric region, all evidence was against a disease gene in our families. Also the data obtained for the distal part of 18q, argue against a genetic susceptibility factor in our sample.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastorno Bipolar
/
Cromosomas Humanos Par 18
/
Ligamiento Genético
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
J Affect Disord
Año:
1997
Tipo del documento:
Article
País de afiliación:
Bélgica