Serological indicators of Helicobacter pylori infection in adult dyspeptic patients and healthy blood donors.
Microbiol Immunol
; 41(5): 387-93, 1997.
Article
en En
| MEDLINE
| ID: mdl-9194037
ABSTRACT
The levels of IgM, IgG and IgA antibodies reacting with two Helicobacter pylori antigens (glycine acid extract (GE) and a recombinant CagA protein) were determined in the sera from adult dyspeptic patients, positive (H.p.(+)) or negative (H.p.(-)) for H. pylori urease/culture, and from healthy blood donors. All sera were also examined against GE by Western blot (Immunoblot) technique. Similar levels of anti-GE IgG were detected in the sera from all H.p.(+) and almost all H.p.(-) patients and from over 40% of the healthy volunteers. In contrast, higher levels of anti-GE IgA were found in the sera from patients than that from healthy subjects, although such antibodies were not detected in the sera from 30% of the H.p.(+) patients. In general, our results suggest that a combination of ELISA and immunoblot may be more sensitive in the detection of H. pylori infection in dyspeptic patients than the examination of biopsy specimens by culturing or histology.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Dispepsia
/
Anticuerpos Antibacterianos
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Microbiol Immunol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Polonia