Interleukin-6 secreting phaeochromocytoma associated with clinical markers of inflammation.
Clin Endocrinol (Oxf)
; 46(4): 507-9, 1997 Apr.
Article
en En
| MEDLINE
| ID: mdl-9196615
ABSTRACT
Phaeochromocytomas have been shown to produce not only catecholamines but other neuropeptides and hormones, with a variety of clinical manifestations. We report a 70-year-old female patient with phaeochromocytoma exhibiting sustained hypertension, low-grade fever, thrombocytosis, and elevated levels of plasma fibrinogen and C-reactive protein. Serum interleukin (IL)-6 levels were significantly elevated, whereas serum IL-1 alpha and IL-1 beta were not detectable. After surgical removal of the tumour, hypertension and low-grade fever disappeared, and the laboratory finding including serum IL-6 concentrations became normal. Immunohistochemical study of the tumour showed positive staining for IL-6. Culture of the resected tumour revealed the production of large amounts of IL-6. It is suggested that IL-6 secreted by the tumour was responsible for some of the clinical manifestations in this patient.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Feocromocitoma
/
Interleucina-6
/
Neoplasias de las Glándulas Suprarrenales
/
Proteínas de Neoplasias
Tipo de estudio:
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón