Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2.
J Biol Chem
; 272(27): 16725-8, 1997 Jul 04.
Article
en En
| MEDLINE
| ID: mdl-9201973
ABSTRACT
Bcl-2 is an intracellular membrane-associated protein that prevents cell death induced by a variety of apoptotic stimuli. A mechanism by which Bcl-2 exerts an anti-cell death effect is, however, not fully understood. In the present study, Bcl-2 suppressed cell death of N18TG neuroglioma cells caused by various apoptotic stresses, including etoposide, staurosporine, anisomycin, and ultraviolet irradiation. Concomitantly, Bcl-2 disrupted a signaling cascade to the c-Jun N-terminal kinase activation induced by the apoptotic stresses. Bcl-2 also prevented the etoposide-induced stimulation of MEKK1. Furthermore, overexpression of c-Jun N-terminal kinase antagonized the death-protective function of Bcl-2. These data suggest that suppression of the c-Jun N-terminal kinase signaling pathway may be critical for Bcl-2 action.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Apoptosis
/
Proteínas Quinasas Dependientes de Calcio-Calmodulina
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Proteínas Proto-Oncogénicas c-bcl-2
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Proteínas Quinasas Activadas por Mitógenos
Límite:
Animals
Idioma:
En
Revista:
J Biol Chem
Año:
1997
Tipo del documento:
Article