Antigenic variability of an immunodominant region (239-261) of the surface glycoprotein of HTLV-I.
Leukemia
; 11 Suppl 3: 17-20, 1997 Apr.
Article
en En
| MEDLINE
| ID: mdl-9209283
ABSTRACT
In the 239-261 region of the surface glycoprotein of HTLV-I, we delineated five epitopes recognized by antibodies present in sera from HTLV-I infected patients. Three epitopes are located between the amino acids 252 and 261, one is of a linear type and the two others of a conformational type. One epitope is comprised between amino acids 244 and 249. The last epitope described lies between the amino acids 244 and 257 and strictly requires the presence of a serine at position 250 for its recognition. When patients are infected by viral isolates presenting a substitution of the serine at position 250 by a proline, no antibodies recognizing the 244-257 region could be found. Altogether, our data demonstrate that the immunodominant 239-261 region is complex and is subject to antigenic variability.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Variación Antigénica
/
Virus Linfotrópico T Tipo 1 Humano
/
Infecciones por HTLV-I
Límite:
Humans
Idioma:
En
Revista:
Leukemia
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
1997
Tipo del documento:
Article
País de afiliación:
Francia