Protective effect against Rhodococcus equi infection in mice of IgG purified from horses vaccinated with virulence associated protein (VapA)-enriched antigens.
Vet Microbiol
; 56(3-4): 187-92, 1997 Jun 16.
Article
en En
| MEDLINE
| ID: mdl-9226833
ABSTRACT
IgG was purified from horses immunized with repeated doses of virulence associated (VapA) enriched antigens extracted with Triton X-114 from the surface of a virulent strain of R. equi. This IgG were administered to mice immunosuppressed by prior treatment with indomethacin. Mice administered the higher dose were completely protected against intraperitoneal infection with R. equi; mice given the lower dose were partially protected. By contrast, mice administered concentrated nonimmune equine IgG were not protected. This study demonstrates that VapA may be an important antigen involved in humoral protective immunity in R. equi infections caused by foal virulent strains.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Infecciones por Actinomycetales
/
Inmunoglobulina G
/
Vacunas Bacterianas
/
Inmunización Pasiva
/
Rhodococcus equi
/
Factores de Virulencia
/
Enfermedades de los Caballos
/
Lipoproteínas
/
Antígenos Bacterianos
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Vet Microbiol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Argentina