Distance-dependent electron transfer in DNA hairpins.
Science
; 277(5326): 673-6, 1997 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-9235887
ABSTRACT
The distance dependence of photoinduced electron transfer in duplex DNA was determined for a family of synthetic DNA hairpins in which a stilbene dicarboxamide forms a bridge connecting two oligonucleotide arms. Investigation of the fluorescence and transient absorption spectra of these hairpins established that no photoinduced electron transfer occurs for a hairpin that has six deoxyadenosine-deoxythymidine base pairs. However, the introduction of a single deoxyguanosine-deoxycytidine base pair resulted in distance-dependent fluorescence quenching and the formation of the stilbene anion radical. Kinetic analysis suggests that duplex DNA is somewhat more effective than proteins as a medium for electron transfer but that it does not function as a molecular wire.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Electrones
/
Conformación de Ácido Nucleico
Idioma:
En
Revista:
Science
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos