Verification of exposure to sulfur mustard in two casualties of the Iran-Iraq conflict.
J Anal Toxicol
; 21(4): 249-51, 1997.
Article
en En
| MEDLINE
| ID: mdl-9248939
ABSTRACT
The exposure of two Iranian victims of the Iran-Iraq conflict (1980-1988) to sulfur mustard was established by immunochemical and mass spectrometric analysis of blood samples taken 22 and 26 days after alleged exposure. One victim suffered from skin injuries compatible with sulfur mustard intoxication but did not have lung injuries; the symptoms of the other victim were only vaguely compatible with sulfur mustard intoxication. Both patients recovered. Immunochemical analysis was based on detection of the N7-guanine adduct of the agent in DNA from lymphocytes and granulocytes, whereas the N-terminal valine adduct in globin was determined by gas chromatography-mass spectrometry after a modified Edman degradation. The valine adduct levels correspond with those found in human blood after in vitro treatment with 0.9 microM sulfur mustard.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de la Piel
/
Células Sanguíneas
/
Sustancias para la Guerra Química
/
Síndrome del Golfo Pérsico
/
Gas Mostaza
Límite:
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Anal Toxicol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Países Bajos