Autologous versus allogeneic T cell-stimulated IL-6 production by dermal fibroblasts.
Inflammation
; 21(4): 371-8, 1997 Aug.
Article
en En
| MEDLINE
| ID: mdl-9276760
ABSTRACT
T cells adhere to human dermal fibroblasts (HDF). This cellular interaction leads to a pronounced secretion of the proinflammatory cytokines IL-6 and IL-8 via a juxtacrine stimulation induced by HDF-associated IL-1. Upon stimulation, fibroblasts express various surface proteins such as MCH-I molecules, which may interact with corresponding receptors on T cells. The present study was conducted to further investigate the mechanism of this complex interaction with regard to the secretion of IL-6 in cocultures of T cells and HDF. IL-6 was time- and dose-dependently upregulated in such cocultures. Spatial separation of the cells by microporous membranes resulted in a 90% reduction of IL-6 secretion, but when cells had limited cell contact IL-6 secretion was increased again. Allogeneic cocultures of T cells and HDF showed increased capacity of IL-6 stimulation as compared to autologous cultures. Our results suggest that MHC-I/T cell receptor interaction modulates IL-6 secretion in allogeneic and autologous cocultures.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piel
/
Linfocitos T
/
Interleucina-6
Límite:
Humans
Idioma:
En
Revista:
Inflammation
Año:
1997
Tipo del documento:
Article
País de afiliación:
Suiza