Immunomodulatory responses to delta-opioid receptor ligands in human lymphocytes.
Eur J Pharmacol
; 332(2): R1-2, 1997 Aug 06.
Article
en En
| MEDLINE
| ID: mdl-9286627
ABSTRACT
In phytohemagglutinin (PHA) activated human peripheral blood mononuclear cells. [3H]thymidine uptake and interferon gamma production were increased by the delta-opioid receptor agonist, deltorphin-I (10(-14)-10(-10) M) and by the delta-opioid antagonist naltrindole (10(-13)-10(-9) M). Combination of 10-9 M naltrindole with deltrophin-I (10(-12)-10(-8)M) significantly inhibited the proliferative response but did not affect interferon production.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligopéptidos
/
Leucocitos Mononucleares
/
Receptores Opioides delta
/
Naltrexona
Límite:
Humans
Idioma:
En
Revista:
Eur J Pharmacol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia