Identification of a naturally occurring peroxidase-lipoxygenase fusion protein.
Science
; 277(5334): 1994-6, 1997 Sep 26.
Article
en En
| MEDLINE
| ID: mdl-9302294
ABSTRACT
A distant relative of catalase that is specialized for metabolism of a fatty acid hydroperoxide was identified. This heme peroxidase occurs in coral as part of a fusion protein, the other component of which is a lipoxygenase that forms the hydroperoxide substrate. The end product is an unstable epoxide (an allene oxide) that is a potential precursor of prostaglandin-like molecules. These results extend the known chemistry of catalase-like proteins and reveal a distinct type of enzymatic construct involved in the metabolism of polyunsaturated fatty acids.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peroxidasas
/
Lipooxigenasa
/
Cnidarios
/
Peroxidasa
/
Oxidorreductasas Intramoleculares
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos