Increased apoptosis rate by hyperthermochemoradiotherapy for advanced rectal cancers.
Surg Today
; 27(8): 773-6, 1997.
Article
en En
| MEDLINE
| ID: mdl-9306598
ABSTRACT
Apoptosis induced in cancer cells by ionizing radiation, hyperthermia, and 5-fluorouracil (5-FU), termed "hyperthermochemoradiotherapy" (HCR), has been well studied in vitro; however, the role of apoptosis in the tumocidal effect of HCR for primary rectal cancers has not yet been clarified. Therefore, we examined the relationship between the therapeutic effect and induction rate of histological apoptosis in 16 patients with rectal cancers after HCR. Numerous Tunel-positive apoptotic cells were found in the tumor tissue after HCR, but few were found in the tumors which had not received HCR. The histological therapeutic effect was closely correlated to the rate of apoptosis. Thus, we suggest that HCR induces a therapeutic effect mainly through apoptosis in human rectal cancers.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias del Recto
/
Apoptosis
/
Fluorouracilo
/
Hipertermia Inducida
/
Antimetabolitos Antineoplásicos
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Surg Today
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón