Randomised, double blind, placebo controlled clinical trial of efficacy of vitamin A treatment in non-measles childhood pneumonia.
BMJ
; 315(7107): 505-10, 1997 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-9329303
ABSTRACT
OBJECTIVE:
To evaluate the impact on clinical recovery and severity of the addition of large doses of vitamin A to the standard treatment for childhood pneumonia.DESIGN:
A randomised, double blind, placebo controlled trial.SETTING:
Study children were recruited at a public hospital in Recife, north east Brazil, an area of marginal vitamin A deficiency.SUBJECTS:
472 children aged 6 to 59 months with clinical diagnosis of pneumonia.INTERVENTIONS:
200,000 IU (infants) or 400,000 IU (1-4 year olds) of vitamin A in oil or similar capsules of placebo divided into two daily oral doses, in addition to the standard treatment. MAIN OUTCOMEMEASURES:
Duration of the episode and incidence of adverse outcomes.RESULTS:
The groups were similar with respect to overall duration of pneumonia and incidence of adverse outcomes. Children who received vitamin A, however, were less likely to have fever by day 3 (P = 0.008) and were 29% less likely to fail to respond to the first line antibiotic (P = 0.054).CONCLUSION:
There was little evidence for an effect of vitamin A treatment on the immediate outcome of the pneumonia episode.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neumonía
/
Vitamina A
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Child, preschool
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Female
/
Humans
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Infant
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Male
Idioma:
En
Revista:
BMJ
Asunto de la revista:
MEDICINA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil