Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats.
Neuroreport
; 8(14): 3009-13, 1997 Sep 29.
Article
en En
| MEDLINE
| ID: mdl-9331907
ABSTRACT
Ovariectomized adult Long-Evans rats received an eight-trial training session in a hippocampal-dependent hidden platform water maze task. Following trial 8, rats received an intra-hippocampal injection of estradiol in a water soluble cyclodextrin inclusion complex (1.0, 2.0 or 5.0 micrograms/0.5 microliter), or saline. Twenty-four hours later, the retention test escape latencies of rats administered post-training intra-hippocampal injections of estradiol (5.0 micrograms) were significantly lower than those of saline treated rats, indicating a memory-enhancing effect of estradiol. Injections of estradiol (5.0 micrograms) given 2 h post-training had no effect on retention, indicating a time-dependent effect of estradiol on memory storage processes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Aprendizaje por Laberinto
/
Estradiol
/
Hipocampo
/
Memoria
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos