Tilidine does not affect human sphincter of Oddi motility--a randomized, controlled study.
Aliment Pharmacol Ther
; 11(5): 987-92, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9354211
ABSTRACT
AIM:
To investigate the effects of intravenous pentazocine and tilidine on sphincter of Oddi motility.METHODS:
Twenty patients with suspected sphincter of Oddi dysfunction were enrolled in a prospective, double-blind study. Sphincter of Oddi motility was assessed by means of endoscopic manometry after injection of 0.9% saline, as well as after randomized dosing with either 30 mg pentazocine i.v. (n = 10) or 50 mg tilidine i.v. (n = 10).RESULTS:
Pentazocine significantly increased the sphincter of Oddi baseline pressure from 32 +/- 21 mmHg (saline) to 41 +/- 19 mmHg (P = 0.002), whereas tilidine did not alter the sphincter baseline pressure (34 +/- 15 mmHg saline vs. 36 +/- 16 mmHg tilidine, P = 0.16). Furthermore, pentazocine increased the phasic sphincter contraction amplitude (108 +/- 16 mmHg saline vs. 121 +/- 18 mmHg pentazocine, P = 0.004), but tilidine was without any effect (125 +/- 24 mmHg saline vs. 125 +/- 21 mmHg tilidine, P = 0.93). The phasic sphincter of Oddi contraction frequency and duration were not influenced either by pentazocine or by tilidine.CONCLUSION:
In contrast to 30 mg of pentazocine, 50 mg of tilidine does not affect sphincter of Oddi motility. Therefore, tilidine can be used during endoscopic manometry and for analgesia in pancreatobiliary disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tilidina
/
Enfermedades del Conducto Colédoco
/
Analgésicos Opioides
/
Esfínter de la Ampolla Hepatopancreática
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Aliment Pharmacol Ther
Asunto de la revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
1997
Tipo del documento:
Article
País de afiliación:
Alemania