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A restriction fragment length polymorphism assay that differentiates human N-acetyltransferase-1 (NAT1) alleles.
Deitz, A C; Doll, M A; Hein, D W.
Afiliación
  • Deitz AC; Department of Pharmacology and Toxicology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, 58202, USA.
Anal Biochem ; 253(2): 219-24, 1997 Nov 15.
Article en En | MEDLINE | ID: mdl-9367506
Currently there is much interest in the N-acetyltransferase-1 (NAT1) genetic polymorphism and its relationship to cancer. Previous studies have described methods to distinguish NAT1 alleles through polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) and/or allele-specific amplification. However, these methods detect at most only four of the NAT1 alleles identified in human populations. In this paper we describe a PCR-RFLP-based assay that differentiates among eight human NAT1 alleles (NAT1*3, *4, *5, *10, *11, *14, *15, *16). This method should prove useful in molecular epidemiological studies investigating associations between NAT1 genotype and cancer.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arilamina N-Acetiltransferasa / Polimorfismo de Longitud del Fragmento de Restricción / Alelos / Isoenzimas Límite: Humans / Male Idioma: En Revista: Anal Biochem Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arilamina N-Acetiltransferasa / Polimorfismo de Longitud del Fragmento de Restricción / Alelos / Isoenzimas Límite: Humans / Male Idioma: En Revista: Anal Biochem Año: 1997 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos