A sero-epidemiological study of the relationship between sexually transmitted agents and cervical cancer in Honduras.
Int J Cancer
; 73(6): 781-5, 1997 Dec 10.
Article
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| MEDLINE
| ID: mdl-9399651
ABSTRACT
To investigate a possible cause-and-effect relationship between sexually transmitted diseases and cervical cancer, we performed a sero-epidemiological study on the presence of antibodies against a number of sexually transmitted agents (STAs) in patients with cervical cancer and their matched controls. In this study, we used serological techniques to investigate the presence of antibodies to cytomegalovirus, herpes simplex virus type 2, human immunodeficiency virus, Chlamydia trachomatis, Treponema pallidum and human papillomavirus (HPV) early protein E7 in sera from patients with cervical cancer, cervical intra-epithelial neoplasia and individually matched, healthy controls. The presence of antibodies to infectious agents other than HPV appeared not to be associated with risk of cervical neoplasia in either univariate or multivariate analysis. After adjustment for cytology, schooling and presence of HPV DNA in cervical scrapes, there was a significantly higher prevalence of antibodies to HPV-16 E7 protein in sera from patients with cervical cancer (OR = 3.6, 95% CI 1.0-12.9) than in healthy controls. The highest antibody prevalence was found among HPV-16 DNA-positive cervical cancer patients (33%). Our results indicate that in these study groups past infections with the STA considered seems to be of no apparent relevance for cervical carcinogenesis and that the HPV-16 anti-E7 response appears to be associated with cervical cancer.
Palabras clave
Americas; Cancer; Case Control Studies; Central America; Cervical Cancer; Developing Countries; Diseases; Epidemiology; Examinations And Diagnoses; Health; Honduras; Hpv; Infections; Laboratory Examinations And Diagnoses; Latin America; Measurement; Neoplasms; North America; Prevalence; Public Health; Reproductive Tract Infections; Research Methodology; Research Report; Sexually Transmitted Diseases; Studies; Viral Diseases
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Bacterianas de Transmisión Sexual
/
Enfermedades Virales de Transmisión Sexual
/
Neoplasias del Cuello Uterino
/
Anticuerpos Antibacterianos
/
Anticuerpos Antivirales
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
America central
/
Honduras
Idioma:
En
Revista:
Int J Cancer
Año:
1997
Tipo del documento:
Article
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA