Chemistry of nitrosoureas. Decomposition of Deuterated 1,3-bis(2-chloroethyl)-1-nitrosourea.
J Med Chem
; 19(7): 958-61, 1976 Jul.
Article
en En
| MEDLINE
| ID: mdl-940114
ABSTRACT
BCNU-alpha-d4 [1,3-bis(2-chloro-1,1-dideuterioethyl)-1-nitrosourea] and BCNU-beta-d4 [1,3-bis(2-chloro-2,2-dideuterioethyl)-1-nitrosourea] were synthesized and decomposed in buffered (pH 7.4)water. The products were analyzed by GC-MS. The deuterium distribution in the products is inconsistent with vinylcarbonium ion or diazochloroethane intermediacy but is consistent with a 2-chloroethylcarbonium ion intermediate with some rearrangement to the 1-chloroethylcarbonium ion and the cyclic chloronium ion.
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01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carmustina
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1976
Tipo del documento:
Article