The frequency and spectrum of congenital anomalies in natural family planning users in South America: no increase in a case-control study. NFP-ECLAMC Group. Natural Family Planning. Latin-American Collaborative Study of Congenital Malformations.
Adv Contracept
; 13(4): 395-404, 1997 Dec.
Article
en En
| MEDLINE
| ID: mdl-9404549
ABSTRACT
Users of natural family planning (NFP) practice periodic abstinence, leading many to reason that such couples should show increased anomalies in offspring as a result of fertilization involving aging gametes. In an effort to complement our NFP cohort study, we currently conducted a case-control study in the same region (South America) in which the largest number of cases have been recruited for our cohort NFP study. During 1992-94, 5324 case-control pairs of mothers were interviewed during the immediate postpartum period in 18 maternity hospitals participating in the Latin-American Collaborative Study of Congenital Malformations ECLAMC (Spanish acronym for Latin-American Collaborative Study of Congenital Malformations). Natural family planning (NFP) usage was recorded in 6% of mothers in the ECLAMC sample studied (n = 10,648). Overall, no significant differences in frequency of NFP usage were observed between malformed cases (349/5324 = 6.6%) and normal controls (303/5324 = 5.7%) (chi 2 = 3.3; df = 1; p > 0.05). No significant differences in sex ratios were observed between children of NFP user and non-user mothers. Of special interest is the lack of association between NFP and Down syndrome, the sentinel phenotype for the hypothesis of delayed fertilization (aging gametes).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Métodos Naturales de Planificación Familiar
/
Anomalías Congénitas
/
Servicios de Planificación Familiar
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
País/Región como asunto:
America do sul
Idioma:
En
Revista:
Adv Contracept
Asunto de la revista:
SERVICOS DE PLANEJAMENTO FAMILIAR
Año:
1997
Tipo del documento:
Article
País de afiliación:
Brasil