Antisecretory factor suppresses intestinal inflammation and hypersecretion.
Gut
; 41(5): 642-5, 1997 Nov.
Article
en En
| MEDLINE
| ID: mdl-9414971
ABSTRACT
BACKGROUND:
Antisecretory factor (AF) is a recently identified regulatory protein which inhibits the intestinal fluid secretion induced by cholera toxin.AIMS:
To test the effect of AF on (a) inflammation and hypersecretion induced by toxin A from Clostridium difficile; and (b) morphological changes and hypersecretion induced by okadaic acid (the blue mussel toxin) in rat intestinal mucosa.METHODS:
Morphological changes and fluid accumulation were observed in intestinal loops challenged with 1 microgram of toxin A or 3 micrograms of okadaic acid administered before or after injection of 0.1 microgram of recombinant AF (rAF).RESULTS:
The cytotoxic and inflammatory reaction caused by toxin A was abolished after treatment with rAF given either intraveneously or intraluminally prior to the toxin or one hour after the toxin. The intestinal fluid response induced by toxin A and okadaic acid was reduced 55-80% by rAF. However, the characteristic increase in goblet cells at the tips of villi in the okadaic acid treated mucosa was not inhibited by rAF.CONCLUSION:
Results suggest that AF might be involved in protection against inflammation and in counteracting dehydration caused by enterotoxins. Both effects are probably mediated via the enteric nervous system.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Toxinas Bacterianas
/
Neuropéptidos
/
Clostridioides difficile
/
Ácido Ocadaico
/
Enterotoxinas
/
Intestinos
/
Antidiarreicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Gut
Año:
1997
Tipo del documento:
Article
País de afiliación:
Suecia