Perfluoroctyl bromide as a blood pool contrast agent for computed tomographic angiography.
Acad Radiol
; 1(2): 151-3, 1994 Oct.
Article
en En
| MEDLINE
| ID: mdl-9419479
ABSTRACT
RATIONALE AND OBJECTIVES:
We determined whether perfluoroctyl bromide (perflubron) could be used as a computed tomography (CT) angiographic agent by studying vessel visibility (celiac artery, superior mesenteric artery [SMA], and renal arteries) with spiral CT and three-dimensional (3D) reconstructions.METHODS:
Five rhesus monkeys were examined with a perflubron emulsion (90% [w/v] perfluorochemical; administered intravenously at a dose of 1.5 ml/kg and at a rate of 0.5 ml/sec. Spiral CT was performed immediately and at 5 hr after injection. Three dimensional images of the aorta at the level of the celiac artery, SMA, and renal arteries were reconstructed and blindly rated 0-4 (0 = not seen; 4 = excellent visualization) by two observers.RESULTS:
All the vessels had the best ratings immediately after injection celiac artery, 2.8 +/- 0.42; SMA, 2.7 +/- 0.48; left renal artery, 2.1 +/- 0.99; and right renal artery, 1.2 +/- 1.03. The ratings after the 5-hr delay were as follows celiac artery, 1.3 +/- 1.34; SMA, 1.5 +/- 1.08; left renal artery, 1.5 +/- 0.97; and right renal artery, 1.2 +/- 0.79.CONCLUSIONS:
Spiral CT angiography with a perflubron emulsion successfully demonstrated all vessels immediately and at 5 hr after contrast agent infusion. Further refinements of the dose, rate, and reconstruction technique are expected to increase vessel visibility over this wide imaging window.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sangre
/
Angiografía
/
Tomografía Computarizada por Rayos X
/
Medios de Contraste
/
Fluorocarburos
Límite:
Animals
Idioma:
En
Revista:
Acad Radiol
Asunto de la revista:
RADIOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Estados Unidos