The role of smoothing techniques in the interpretation of results from genomic scans using sib-pair data.
Genet Epidemiol
; 14(6): 1047-52, 1997.
Article
en En
| MEDLINE
| ID: mdl-9433622
ABSTRACT
We compare the results of genomic scans conducted with the Haseman-Elston sib-pair method using either (1) the average marker information from several adjacent loci or (2) each marker individually. Under smoothing, the squared sib-pair trait difference is regressed on the average number of alleles shared identical by descent averaged at several adjacent loci. This results in a significant decrease in the number of false-positives when compared to the individual marker approach. Linkage of Q4 to MG4 was found only with smoothing but not the individual marker approach. Overall, smoothing resulted in the loss of two true linkages.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleo Familiar
/
Marcadores Genéticos
/
Genoma Humano
/
Pruebas Genéticas
/
Interpretación Estadística de Datos
/
Carácter Cuantitativo Heredable
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Genet Epidemiol
Asunto de la revista:
EPIDEMIOLOGIA
/
GENETICA MEDICA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos