The HLA-A*0207 peptide binding repertoire is limited to a subset of the A*0201 repertoire.
Hum Immunol
; 58(1): 12-20, 1997 Nov.
Article
en En
| MEDLINE
| ID: mdl-9438205
ABSTRACT
Quantitative A*0207 peptide binding assays have been developed utilizing HLA transfected cells and affinity purified molecules. By using a panel of single substitution analog peptides, it was demonstrated that A*0207 binds peptides with main anchor specificity at position 2 and the C-terminus similar to A*0201. Previous data indicating that A*0207 (but not A*0201) also requires the presence of D or P in position 3 of its peptide ligands was confirmed by the analysis of additional single substituted analogs. Finally, by analyzing the A*0201 and A*0207 binding capacities of panels of unrelated synthetic peptides, it was found that 8/15 (53.3%) A*0201 binders with D or P in position 3 bound A*0207, while only 5/72 (6.9%) A*0201 binders without D or P in position 3 also bound A*0207. Together, these data indicate that although A*0207 may be included amongst A2 supertype alleles, its peptide binding repertoire is largely limited to a subset of that bound by A*0201.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Antígeno HLA-A2
Límite:
Humans
Idioma:
En
Revista:
Hum Immunol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos