Comparison of CO2 generation (BACTEC) and viable-count methods to determine the postantibiotic effect of antimycobacterial agents against Mycobacterium avium complex.
Antimicrob Agents Chemother
; 42(1): 184-7, 1998 Jan.
Article
en En
| MEDLINE
| ID: mdl-9449284
ABSTRACT
The postantibiotic effects (PAEs) of antimycobacterial agents determined with a BACTEC TB-460 instrument (CO2 production) and by a traditional viable-count method against Mycobacterium avium complex (MAC) were not significantly different (P > 0.05). The longest PAEs following a 2-h exposure to 2x the MIC were induced by amikacin (10.3 h), rifampin (9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is a valid and efficient means of determining in vitro PAEs against MAC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dióxido de Carbono
/
Complejo Mycobacterium avium
/
Antituberculosos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
1998
Tipo del documento:
Article
País de afiliación:
Canadá