Source of extracellular brain adenosine during hypoxia in fetal sheep.
Brain Res
; 778(2): 439-42, 1997 Dec 19.
Article
en En
| MEDLINE
| ID: mdl-9459565
ABSTRACT
Microdialysis was performed to determine whether hypoxia increases fetal brain adenosine (ADO) concentration through dephosphorylation of extracellular 5'-adenosine monophosphate (5-AMP). Hypoxia (fetal PaO2 approximately 14 Torr) increased fetal brain ADO levels approximately two-fold when the probes were perfused with synthetic cerebrospinal fluid (CSF) containing inhibitors of the nucleoside transporter but not with this solution plus a blocker of ecto-5'-nucleotidase (AOPCP). The hypoxia-induced rise in fetal brain ADO concentrations depends critically upon the hydrolysis of extracellular 5'-AMP.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Respiración
/
Adenosina Monofosfato
/
Hipoxia Fetal
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Brain Res
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos