Simulated ischaemia-reperfusion conditions increase xanthine dehydrogenase and oxidase activities in rat brain slices.
Neurochem Int
; 32(1): 17-21, 1998 Jan.
Article
en En
| MEDLINE
| ID: mdl-9460697
ABSTRACT
Xanthine dehydrogenase and oxidase activities increased by 87% in rat brain slices after 30 min in vitro ischaemia. A further 41% increase was induced by 30 min simulated reperfusion of ischaemic slices. No conversion from the dehydrogenase to the oxidase activity was observed. The increment of enzyme activity was not due to neosynthesis of the enzyme, since it was not affected by the addition of cycloheximide during the ischaemic incubation. The increased oxygen-dependent form of the enzyme could aggravate the ischaemic brain injury by free radicals production, in particular after reperfusion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Xantina Deshidrogenasa
/
Xantina Oxidasa
/
Encéfalo
/
Reperfusión
/
Ataque Isquémico Transitorio
/
Modelos Biológicos
Límite:
Animals
Idioma:
En
Revista:
Neurochem Int
Año:
1998
Tipo del documento:
Article
País de afiliación:
Italia