High concentration of glucose causes impairment of the function of the glutathione redox cycle in human vascular smooth muscle cells.
FEBS Lett
; 421(1): 19-22, 1998 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-9462831
ABSTRACT
We demonstrated that high glucose reduced H2O2 scavenge activity in human vascular smooth muscle cells. In the cells exposed to high glucose, the intracellular glutathione content decreased, although the NADPH content was unchanged. The rate of uptake of cystine, which is a rate-limiting precursor of the glutathione synthesis, decreased in the high glucose group compared with the control group. These decreases were shown to be dependent on glucose concentration. It was suggested that high glucose causes impairment of the function of the glutathione redox cycle in human vascular smooth muscle cells, resulting in reduced H2O2 scavenge activity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glucosa
/
Glutatión
/
Músculo Liso Vascular
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón