The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor.
J Exp Med
; 187(4): 571-8, 1998 Feb 16.
Article
en En
| MEDLINE
| ID: mdl-9463407
ABSTRACT
The orphan receptor CRF2-4 is a member of the class II cytokine receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor. CRFB4, the gene encoding CRF2-4, is located within a gene cluster on human chromosome 21 that comprises three interferon receptor subunits. To elucidate the role of CRF2-4, we disrupted the CRFB4 gene in mice by means of homologous recombination. Mice lacking CRF2-4 show no overt abnormalities, grow normally, and are fertile. CRF2-4 deficient cells are normally responsive to type I and type II interferons, but lack responsiveness to IL-10. By approximately 12 wk of age, the majority of mutant mice raised in a conventional facility developed a chronic colitis and splenomegaly. Thus, CRFB4 mutant mice recapitulate the phenotype of IL-10-deficient mice. These findings suggest that CRF2-4 is essential for IL-10-mediated effects and is a subunit of the IL-10 receptor.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Receptores de Interleucina
/
Receptores de Citocinas
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos