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Lack of type 1 and type 2A myosin heavy chain isoforms in rat slow muscle regenerating during chronic nerve block.
Midrio, M; Danieli-Betto, D; Esposito, A; Megighian, A; Carraro, U; Catani, C; Rossini, K.
Afiliación
  • Midrio M; Istituto di Fisiologia Umana, Università di Padova, Padua, Italy.
Muscle Nerve ; 21(2): 226-32, 1998 Feb.
Article en En | MEDLINE | ID: mdl-9466598
The degeneration-regeneration process was induced by bupivacaine injection in innervated, denervated, and nerve-blocked rat soleus muscles. Nerve block was obtained by superfusion of the sciatic nerve with tetrodotoxin (TTX). Two weeks after bupivacaine injection, immunohistochemical and electrophoretical analyses showed the presence of type 1 myosin heavy chain (MHC) only in innervated regenerated muscles, type 2A in innervated and denervated, but not in TTX-paralyzed muscles, and type 2X under all experimental conditions. The presence of type 1 MHC in the innervated, and its absence in both denervated and TTX-paralyzed muscles were also verified immunohistochemically 1 week after bupivacaine injection. It is concluded that the nerve impulses play a determinant role in the expression of 1 and 2A MHC isoforms in the innervated regenerating muscle. The possible causes of the absence of the type 2A MHC isoform in the TTX-paralyzed muscles are discussed.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Fibras Musculares de Contracción Lenta / Cadenas Pesadas de Miosina / Bloqueo Nervioso Límite: Animals Idioma: En Revista: Muscle Nerve Año: 1998 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Fibras Musculares de Contracción Lenta / Cadenas Pesadas de Miosina / Bloqueo Nervioso Límite: Animals Idioma: En Revista: Muscle Nerve Año: 1998 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos