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Identification of an atypical lipoprotein-binding protein from human aortic smooth muscle as T-cadherin.
Tkachuk, V A; Bochkov, V N; Philippova, M P; Stambolsky, D V; Kuzmenko, E S; Sidorova, M V; Molokoedov, A S; Spirov, V G; Resink, T J.
Afiliación
  • Tkachuk VA; Laboratory of Molecular Endocrinology, Institute of Experimental Cardiology, Cardiology Research Center, Moscow, Russia.
FEBS Lett ; 421(3): 208-12, 1998 Jan 16.
Article en En | MEDLINE | ID: mdl-9468307
We have previously described an atypical lipoprotein-binding protein of about 105 kDa (p105) in membranes of vascular smooth muscle cells (VSMCs) that is distinct from currently known lipoprotein receptors. In the present work we have developed a procedure for purification of p105 from human aortic media. Partial sequencing of purified protein has revealed identity of p105 with human T-cadherin. Anti-peptide antisera raised against human T-cadherin recognized a protein spot corresponding to the purified p105 on two-dimensional Western blots. The antisera also inhibited LDL binding to p105 on ligand blots. We conclude that the 105 kDa lipoprotein-binding protein present in human VSMCs is T-cadherin, an unusual glycosylphosphatidylinositol-anchored member of the cadherin family of cell-cell adhesion proteins.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Cadherinas / Lipoproteínas LDL / Músculo Liso Vascular Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: FEBS Lett Año: 1998 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Cadherinas / Lipoproteínas LDL / Músculo Liso Vascular Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: FEBS Lett Año: 1998 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido