Structure, functions, and evolution of the third complement component and viral molecular mimicry.
Immunol Res
; 17(1-2): 109-21, 1998.
Article
en En
| MEDLINE
| ID: mdl-9479573
ABSTRACT
The third component of the complement system, C3, is a common denominator in the activation of the classical, alternative, and lectin pathways. The ability of C3 molecule to interact with at least 20 different proteins makes it the most versatile component of this system. Since these interactions are important for phagocytic, immunoregulatory, and immune evasion mechanisms, the analysis of its structure and functions has been a subject of intense research. Here we review our current work on the C3-ligand interactions, C3-related viral molecular mimicry, evolution of the complement system, and identification of C3-based complement inhibitors.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Complemento C3
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Res
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos