[Experimental isovolemic hemodilution. Study of tissue perfusion with Hb 3% in swine]. / Emodiluizione isovolemica sperimentale. Studio sulla perfusione tessutale ad Hb 3 g% nel suino.
Minerva Anestesiol
; 63(7-8): 229-36, 1997.
Article
en It
| MEDLINE
| ID: mdl-9489308
ABSTRACT
BACKGROUND:
The aim of the study is to evaluate the limits of the compensatory mechanisms and the tissue damages caused by the low oxygen content during severe normovolemic hemodilution in pigs.METHODS:
The experimental procedure was performed in 10 animals after general anaesthesia was induced and iso-hypervolemic hemodilution to Hct 10% was maintained for five hours without any intensive care. Hemodynamic, biochemical and ultrastructural parameters were detected before and at the end of hemodilution in addition to analysis of oxygen delivery/uptake and mitochondrial enzymes function.RESULTS:
The collected data show the initial good compensatory mechanism was subsequently exhausted; five animals demonstrated cardiac ischemia and low CO and two of them died before the end of the experiment; no hemodynamic and hemoxymetric data predicted the cardiac ischemia; the dilution caused alterations of some detected biochemical parameters such as hemocoagulation; no evidence of morphologic and ultrastructural tissue damage or interstitial edema; decreasing in mitochondrial enzymes activity significant only for NADH-related.CONCLUSIONS:
In conclusion, it seems that, in pigs at least, the compensatory mechanisms can keep a sufficient tissue oxygen supply throughout the experimental time with the exception of cardiac muscle.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Volumen Sanguíneo
/
Hemoglobinas
/
Hemodilución
Límite:
Animals
Idioma:
It
Revista:
Minerva Anestesiol
Año:
1997
Tipo del documento:
Article