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Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
Mizushima, S; Fujita, M; Ishida, T; Azuma, S; Kato, K; Hirai, M; Otsuka, M; Yamamoto, T; Inoue, J.
Afiliación
  • Mizushima S; Biosciences Research Laboratory, Mochida Pharmaceutical Co. Ltd, Tokyo, Japan.
Gene ; 207(2): 135-40, 1998 Jan 30.
Article en En | MEDLINE | ID: mdl-9511754
ABSTRACT
A cDNA encoding the human homolog of the tumor necrosis factor receptor-associated factor 5 (TRAF5) protein has been molecularly cloned from a cDNA library of Human Daudi B cell line. The sequence analysis revealed that the cDNA encoded a protein of 557 aa residues with a calculated molecular weight of 64,236. The encoded protein has typical structural characteristics shown in the TRAF family of proteins and binds to the cytoplasmic region of lymphotoxin-beta receptor more efficiently than to that of CD40 and CD30. The TRAF5 gene was mapped to the human chromosome 1q32.3-q41.1. Overexpression of human TRAF5 activates NF kappa B transcription factor in human 293T kidney cells. These results suggest that the human TRAF5 protein could be involved in the signal triggered by various members of the tumor necrosis factor receptor (TNFR) superfamily including CD40, CD30 and lymphotoxin-beta receptor.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Proteínas Portadoras / Factor de Necrosis Tumoral alfa Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Gene Año: 1998 Tipo del documento: Article País de afiliación: Japón
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Proteínas Portadoras / Factor de Necrosis Tumoral alfa Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Gene Año: 1998 Tipo del documento: Article País de afiliación: Japón