Your browser doesn't support javascript.
loading
[Epilepsy and disorders of cortical development in children with congenital cytomegalovirus infection]. / Epilepsia y alteraciones del desarrollo cortical en niños con infección congénita por citomegalovirus.
Pérez-Jiménez, A; Colamaria, V; Franco, A; Grimau-Merino, R; Darra, F; Fontana, E; Zullini, E; Beltramello, A; Dalla-Bernardina, B.
Afiliación
  • Pérez-Jiménez A; Servicio de Neuropsiquiatría Infantil, Hospital Policlínico, Universidad de Verona, Italia.
Rev Neurol ; 26(149): 42-9, 1998 Jan.
Article en Es | MEDLINE | ID: mdl-9533204
INTRODUCTION: Neuroimaging and experimental studies have related cytomegalovirus (CMV) to certain neuronal migration disorders. MATERIAL AND METHODS: To define the electroclinical picture of children with epilepsy associated with disorders of cortical development (DCD) and congenital CMV infection, we conducted a clinical, electroencephalographic and neuroradiological study of 10 children with this condition. RESULTS: Eighty per cent of them had dismorphic traits, or malformations outside CNS. All showed other neuroradiological signs (cerebral calcification, white matter damage, porencephaly). Six patients with bihemispheric DCD (agyria-pachigyria, 2; 'poligyria', 1; schizencephaly, 1; bilateral opercular DCD, 2) showed: Tetraparesis, severe or profound mental deficiency, early onset epilepsy (mean age at onset: 11 months) with spasms, tonic seizures, partial seizures, and multifocal paroxysms or unusual diffuse sharp Alfa-Beta EEG activity. One child developed Epilepsia Partialis Continua. Children with bilateral opercular DCD evolved to a continuous spike and wave (SW) electrical status during wakefulness and sleep, linked to a worsening of psychomotor derangement. Four patients with unilateral hemispheric DCD (pachigyric or 'poligyric') showed: Congenital hemiparesis, mild intellectual deficiency, motor seizures (orofacial, hemiclonic, generalized) beginning in the third year of live, atypical absences with focal phenomena, frequent focal rhythmic SW discharges during wakefulness, and continuous SW status during sleep (CSWS). CONCLUSIONS: A wide spectrum of DCD due to congenital CMV infection is documented. Characteristic electroclinical pictures related to the extent and topographical distribution of the DCD are recognized, which may lead to an appropriate diagnosis and prognosis.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Epilepsias Parciales / Epilepsias Mioclónicas / Infecciones por Citomegalovirus Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: Es Revista: Rev Neurol Año: 1998 Tipo del documento: Article País de afiliación: Italia Pais de publicación: España
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Cerebral / Epilepsias Parciales / Epilepsias Mioclónicas / Infecciones por Citomegalovirus Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: Es Revista: Rev Neurol Año: 1998 Tipo del documento: Article País de afiliación: Italia Pais de publicación: España