Regulation of IGFBP-1 and -4 expression by triiodothyronine (T3) in cultured hepatocytes is cell- and gene-specific.
Boll Soc Ital Biol Sper
; 73(3-4): 47-53, 1997.
Article
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| MEDLINE
| ID: mdl-9540232
ABSTRACT
Evidence suggests that thyroid hormone plays a role in the regulation of hepatic IGF/IGFBP expression both in human and rats. In this study we compared the effect of T3 on IGFBP-1 and -4 expression in rat hepatocyte primary cultures and in the human hepatoma cell line HepG2. Northern blot analysis revealed that IGFBP-1 mRNA levels were not affected by T3 in cultured rat hepatocytes, whereas a net increase of IGFBP-1 transcript abundance was induced by the hormone in HepG2 cells. On the contrary, IGFBP-4 mRNA levels were increased in rat hepatocytes cultured in the presence of T3, but unaffected in T3-treated HepG2 cells. Therefore, thyroid hormone seems to regulate hepatic IGFBP expression in a direct and gene-specific way. Moreover, the effects of thyroid hormone depend strictly on the source of target hepatocyte.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triyodotironina
/
Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina
/
Proteína 4 de Unión a Factor de Crecimiento Similar a la Insulina
/
Hígado
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Boll Soc Ital Biol Sper
Año:
1997
Tipo del documento:
Article