Ovalbumin coupled either with murine red blood cells or liposome induces IgG but not IgE antibody production.
Dev Biol Stand
; 92: 353-63, 1998.
Article
en En
| MEDLINE
| ID: mdl-9554291
ABSTRACT
Ovalbumin (OVA) was coupled with murine red blood cells (MRBC) using glutaraldehyde. The OVA-MRBC conjugate induced anti-OVA IgG antibody in mice at almost the same level as OVA in alum. However, no IgE antibody production specific for OVA was observed in OVA-MRBC-injected mice. A significant increase in IGG2a production was obtained with OVA-MRBC immunization, whereas the production of IgG1 predominated in OVA in alum immunization. Am OVA-liposome conjugate induced IgE-specific unresponsiveness in mice in the same manner as OVA-MRBC. Similar results were obtained when antigens other than OVA, such as tetanus toxoid or diphtheria toxoid, were coupled to liposome. These results show the potential of antigen-liposome conjugates for the development of vaccine that induces sufficient IgG antibody production without IgE synthesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina E
/
Inmunoglobulina G
/
Ovalbúmina
/
Eritrocitos
Límite:
Animals
Idioma:
En
Revista:
Dev Biol Stand
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón