Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas.
J Oral Pathol Med
; 27(3): 95-100, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9563799
ABSTRACT
Periapical granulomas contain a large number of T lymphocytes and monocytes/macrophages and a small number of B lymphocytes and polymorphonuclear leukocytes. Sections from eight periapical granulomas were stained by a variety of immunohistochemical methods. The vascular endothelial cells stained positively for intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Helper T cells were identified by immunostaining for CD4 and stained positively for interferon-gamma (IFN-gamma). However, CD4-positive T cells did not stain for interleukin-4 (IL-4). Monocytes/macrophages were identified by immunostaining for CD68 and stained positively for IL-1alpha or inducible nitric oxide synthase (iNOS). IL-1beta could not be detected in the same samples. No cytokine expression was observed in B cells identified by immunostaining for CD20. IFN-gamma- and iNOS-positive cells could not be detected in clinically healthy periodontal ligament being used as a negative control. These results suggest that the IFN-gamma-producing T cells and iNOS-positive cells may modulate the progress of disease in local inflammation sites such as in periapical granulomas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Granuloma Periapical
/
Linfocitos T
/
Interferón gamma
/
Óxido Nítrico Sintasa
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
J Oral Pathol Med
Asunto de la revista:
ODONTOLOGIA
/
PATOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón