Stat3 activation is required for cellular transformation by v-src.
Mol Cell Biol
; 18(5): 2553-8, 1998 May.
Article
en En
| MEDLINE
| ID: mdl-9566875
ABSTRACT
Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-src transformation. Stat3 wild-type or mutant proteins did not affect v-ras transformation. We conclude that Stat3 has a necessary role in v-src transformation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transactivadores
/
Transformación Celular Neoplásica
/
Proteína Oncogénica pp60(v-src)
/
Proteínas de Unión al ADN
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos