Gastric cytoprotective activity of dehydroleucodine in rats. Role of prostaglandins.
Biol Pharm Bull
; 21(4): 335-8, 1998 Apr.
Article
en En
| MEDLINE
| ID: mdl-9586568
ABSTRACT
Previously, we reported that dehydroleucodine (DhL), a sesquiterpene lactone, protected the gastric mucosa of rats from absolute ethanol-induced lesions in a dose-dependent fashion. The mechanism is not mediated by an antiacid secretory action and DhL stimulated mucous production. In the present study, we report the effect of DhL on the mucosal production of prostaglandin E (PGE) and the mucosal release of PGE2 in rats stomach. DhL in acute treatment does not modify these values decreased by previous treatment with indomethacin or absolute ethanol. However, DhL in subchronic treatment significantly enhanced the mucosal production of PGE and the mucosal release of PGE2. Also, indomethacin pretreatment resulted in a significant reduction of the cytoprotective action of DhL. These results indicate the participation of endogenous prostaglandins in DhL protection against ethanol damage. Moreover, we suggest that the gastric protective activity of DhL against ethanol induced gastric mucosal damage is mediated, at least in part, through PGE and PGE2 in subchronic treatment.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prostaglandinas E
/
Sesquiterpenos
/
Mucosa Gástrica
/
Lactonas
/
Antiulcerosos
Límite:
Animals
Idioma:
En
Revista:
Biol Pharm Bull
Asunto de la revista:
BIOQUIMICA
/
FARMACOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Argentina