Effect of copper deficiency on prenatal development and pregnancy outcome.
Am J Clin Nutr
; 67(5 Suppl): 1003S-1011S, 1998 05.
Article
en En
| MEDLINE
| ID: mdl-9587143
ABSTRACT
Copper deficiency during embryonic and fetal development can result in numerous gross structural and biochemical abnormalities. Such a deficiency can arise through a variety of mechanisms, including low maternal dietary copper intake, disease-induced or drug-induced changes in maternal and conceptus copper metabolism, or both. These issues are discussed in this article along with the use of in vitro embryo culture models to study the mechanisms underlying copper deficiency-induced teratogenesis. Current data suggest that changes in free radical defense mechanisms, connective tissue metabolism, and energy production can all contribute to the dysmorphogenesis associated with developmental copper deficiency.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anomalías Congénitas
/
Cobre
/
Desarrollo Embrionario y Fetal
Límite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Am J Clin Nutr
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos