Six-year supplementation with alpha-tocopherol and beta-carotene and age-related maculopathy.
Acta Ophthalmol Scand
; 76(2): 224-9, 1998 Apr.
Article
en En
| MEDLINE
| ID: mdl-9591958
ABSTRACT
PURPOSE:
Animal research and observational studies in man suggest a protective effect of antioxidant vitamins in the development of age-related maculopathy (ARM).METHODS:
The ATBC study, a population-based, controlled clinical trial of alpha-tocopherol and beta carotene to prevent lung cancer, took place in Finland between 1984 and 1993. Over 29,000 smoking males aged 50 to 69 years were randomly assigned to alpha-tocopherol (AT; 50 mg/day), beta-carotene (BC; 20 mg/day), both of these, or placebo. We performed an end-of-trial ophthalmological examination on a random sample of 941 participants aged 65 years or more from two of the fourteen study areas, to discover if the five to eight-year intervention with alpha-tocopherol and/or beta-carotene had been associated with a difference in ARM prevalence. Age-related maculopathy was assessed using colour photographs of the macula.RESULTS:
Altogether, 269 cases of ARM were found; there were more cases in the AT group (32%; 75/237), BC group (29%; 68/234), and combined antioxidant group (28%; 73/257) than in the placebo group (25%; 53/213). However, neither substance was significantly associated with the risk of ARM in a logistic regression analysis controlling for possible risk factors.CONCLUSIONS:
No beneficial effect of long-term supplementation with alpha-tocopherol or beta-carotene on the occurrence of ARM was detected among smoking males.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de la Retina
/
Vitamina E
/
Envejecimiento
/
Beta Caroteno
/
Mácula Lútea
/
Antioxidantes
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Acta Ophthalmol Scand
Asunto de la revista:
OFTALMOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Finlandia