Lamotrigine may limit pathological excitation in the hippocampus by modulating a transient potassium outward current.
Brain Res
; 791(1-2): 330-4, 1998 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-9593976
ABSTRACT
Actions of the new antiepileptic drug lamotrigine were characterised using whole cell patch clamp recordings from rat CA1 pyramidal cells in vitro. The results suggest that lamotrigine, besides its previously described effect on the fast sodium inward current and calcium currents, modulates the transient potassium outward current ID. This may be an effective mechanism to inhibit pathological excitation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triazinas
/
Canales de Potasio
/
Hipocampo
/
Anticonvulsivantes
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1998
Tipo del documento:
Article
País de afiliación:
Alemania