Endothelins inhibit mineralization of rat calvarial osteoblast-like cells.
J Cardiovasc Pharmacol
; 31 Suppl 1: S521-3, 1998.
Article
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| MEDLINE
| ID: mdl-9595531
ABSTRACT
We examined the effects of members of the endothelin (ET) family on mineralization of rat calvarial osteoblast-like cells. The accumulation of calcium in cells and cell layers was attenuated by ETs with the rank order of potency ET-1 = ET-2 > ET-3. We stained the mineralized nodules by von Kossa staining and measured the number and area of mineralized nodules. The inhibitory effects of ET-1 and ET-2 on the formation of mineralized nodules were stronger than those of ET-3. Our data suggest that ET-1 may inhibit the mineralization process of osteoblastic cells through the ETA receptor.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoblastos
/
Cráneo
/
Calcificación Fisiológica
/
Endotelinas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón