Substance P diminishes lipopolysaccharide and interferon-gamma-induced TGF-beta 1 production by cultured murine macrophages.
Cell Immunol
; 183(2): 113-20, 1998 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-9606995
ABSTRACT
Recent evidence has demonstrated the importance of substance P and its receptor in macrophage-mediated inflammatory responses. While previous studies have shown that substance P can augment proinflammatory monokine production, little is known about the effects of this neuropeptide on the production of monokines that might limit inflammation. In the present study we have investigated the effect of substance P treatment on the production of transforming growth factor-beta 1 (TGF-beta 1) in cultured murine macrophages. We report that, while substance P agonist alone elicited increases in TGF-beta 1 mRNA expression and modest increases in TGF-beta 1 secretion, substance P dramatically diminished LPS- or IFN-gamma-induced TGF-beta 1 production. These results suggest a previously unrecognized mechanism where substance P may act as a proinflammatory mediator by limiting the production of excessive levels of TGF-beta 1 by LPS- or IFN-gamma-activated macrophages.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sustancia P
/
Lipopolisacáridos
/
Factor de Crecimiento Transformador beta
/
Interferón gamma
/
Macrófagos Peritoneales
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Cell Immunol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos