A spontaneous seminal vesicle adenocarcinoma in an aged F344 rat.
Toxicol Pathol
; 26(3): 448-51, 1998.
Article
en En
| MEDLINE
| ID: mdl-9608652
ABSTRACT
A rare seminal vesicle adenocarcinoma was found in a 109-wk-old Fischer 344 (F344) rat. At necropsy, the right seminal vesicle was enlarged, containing a 15- x 18- x 18-mm mass. The neoplasm occupied almost the entire seminal vesicle lumen and consisted of epithelial cells arranged in papillary, glandular, and solid patterns. Tumor cells were larger than their normal counterparts in the seminal vesicles and had round nuclei and abundant cytoplasm. Clusters of macrophagelike cells with less abundant cytoplasm and indented nuclei were apparent in the lumina of the glandular structures formed by the tumor cells. No metastasis to other tissues or organs was observed. Immunohistochemically, tumor cells were positive for keratin and S-100, and the macrophagelike cells bound antibodies against vimentin and ED-1. Ultrastructurally, the tumor cells exhibited many small secretory granules, some microvilli, and intercellular junctions. The macrophagelike cells, in contrast, were characterized by lysosomes and abundant rough endoplasmic reticulum. Therefore, a diagnosis of seminal vesicle adenocarcinoma with intraluminal macrophage infiltration was made. This is the first case report of such a seminal vesicle tumor in an F344 rat.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ratas Endogámicas F344
/
Enfermedades de los Roedores
/
Vesículas Seminales
/
Adenocarcinoma
/
Neoplasias de los Genitales Masculinos
Límite:
Animals
Idioma:
En
Revista:
Toxicol Pathol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón